Folic Acid:
Everything You Need to Know About Folic Acid
(Folate, Vit B9) From the Latest Research:
Crucial To Everyone's Health and Longevity
Written by William Bruneau
Publish Date: September 1, 2007
Price $7.95
128 pages
ISBN 0974879916 LCCN: xxx
Sample Page
"One thing is for sure, folate is of great interest and of great clinical value, a veritable panacea among functional foods... it is not hard to envisage a new era in preventive medicine that has even greater emphasis on diet as a means to a long and healthy life, indeed, a return to Hippocrates famous - Let food be thy medicine and medicine be thy food - philosophy." (1)
In recent years, the folates have become the most prominent of the B-complex vitamins... Yet despite their essential
biochemical function of transporting single-carbon fragments in amino acid metabolism and nucleic acid synthesis,
folates were... Not long ago... considered relatively unimportant - even dangerous. The timeline of the folates starts
with a brief period of enthusiasm accompanying its isolation and synthesis, followed by decades of disrepute. Now,
folates have emerged as an indispensable nutrient in areas far removed from their original indications. (2)
The Importance of Folates
Modern research, much of it in the last five years, suggests that folates are the most important vitamin of all. Adequate folate is absolutely essential for everyone's growth, good health and well being. Yet most people, if they are aware of Vitamin B9 at all, think of it as a vitamin for pregnant women.The critical role of folates in your life process has best been shown by how it kills growth in its absence. For decades sulfa drugs have been important antibiotics. Microbes make their own folate; sulfa drugs substitute an anti-folate that cripples their ability to manufacture folates, and as a result they cannot grow or reproduce. (11,13) Anti-malarials work this way as well. (15) Folate antagonists were among the first chemicals to be used in chemotherapy by starving cancer cells of the folates that they need to grow. (12,13)
Folates play crucial roles in the life processes of your cells. (13) Folate is essential for normal cell growth and replication - which is particularly important during infancy and pregnancy. Folate is necessary to create and repair DNA, and it also helps prevent unwanted changes to DNA. (5,6) Currently there is evidence to suggest that folate deficiency significantly affects spontaneous chromosome damage. (3,10)
Folates are essential to the development of the central nervous system. (14) and remain important to the nervous system at all ages. (4) Folates are important in a number of other areas which we will address later.
Historically, folates were first known for preventing anemia and birth defects. During the 1970s and 1980s there was gradual and increasing recognition of the benefits of the vitamin in neuropsychiatric disorders associated with folate-deficiency anemia. By the end of the 1980s folate's connection to heart disease and cancer was well known. (7,8,9) Today there is a long list of disease and conditions linked with folate deficiency. This book contains the most comprehensive list of these diseases and conditions available anywhere.
A dark side of folate has recently emerged. There is some evidence that too much folic acid (synthetic folate) might damage your health and even lead to a premature death [See Toxic or Poisonous Levels of FA ] Some synthetic folates are more efficient and better tolerated by your body. The absolute latest research is included in this book to help you find the right amount and right kind of folate to suit your needs.
All of this information is available on the internet somewhere, but it has taken two years of research to find it. Nearly 40,000 journal articles have been culled for almost a thousand compelling articles that are the basis of this book. Some of the most important research in this book is virtually unknown outside of the scientific community.
Even though this information is from peer-review science journals, some of it is too controversial for many official sources. This is the stuff you need to know - it may save your life. This book is the best source of complete impartial, up-to-date, state-of-the-art information for the public, and would serve well as a handy reference for professionals.
REFERENCES
1 BMJ. 2004 Jan 24;328(7433):211-4Is folic acid the ultimate functional food component for disease prevention?
Lucock M.
Human Nutrition, School of Applied Sciences, University of Newcastle, Brush Road, Ourimbah, NSW 2258, Australia.
2 Modern Drug Discovery, August 2001, Vol. 4, No. 8, pp 63–61, 66
Vicissitudes of a vitamin
STANLEY SCHEINDLIN
3 EVM/00/18.REVISEDAUG2002
[European Union Report on Folate]
EXPERT GROUP ON VITAMINS AND MINERALS REVIEW OF FOLIC ACID
The attached review of folic acid is a slightly revised version of the paper first presented to the Expert Group on Vitamins
and Minerals at the meetings on 1 November 2000, October and 19 December 2001
4 J Neurol Neurosurg Psychiatry. 2002 May;72(5):567-71
Benefits and risks of folic acid to the nervous system
Reynolds EH.
5 Semin Oncol 1997 Oct;24(5 Suppl 18):S18-30-S18-39
Folate and antifolate pharmacology
Kamen B.
Department of Pediatrics, The University of Texas Southwestern Medical Center, Dallas 75235-9063, USA
6 Eur J Nutr. 2001 Jun;40(3):98-105
Beneficial role for folate in the prevention of colorectal and breast cancer
Prinz-Langenohl R, Fohr I, Pietrzik K.
Institute of Nutritional Science, Dept of Pathophysiology of Human Nutrition, University of
Bonn, Germany. r.prinz@uni-bonn.de
7 Journal Of The National Cancer Institute, Vol 85, 875-884
Folate, methionine, and alcohol intake and risk of colorectal adenoma
E Giovannucci, MJ Stampfer, GA Colditz, EB Rimm, D Trichopoulos, BA Rosner, FE
Speizer and WC Willett
Channing Laboratory, Department of Medicine, Harvard Medical School, Boston, MA
8 Ann Intern Med. 1998 Oct 1;129(7):517-24
Multivitamin use, folate, and colon cancer in women in the Nurses' Health Study
Giovannucci E, Stampfer MJ, Colditz GA, Hunter DJ, Fuchs C, Rosner BA, Speizer FE,
Willett WC.
Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
9 JAMA. 1998 Feb 4;279(5):359-64
Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women
Rimm EB, Willett WC, Hu FB, Sampson L, Colditz GA, Manson JE, Hennekens C, Stampfer
Department of Epidemiology, Harvard School of Public Health, Boston, Mass 02115, USA. eric.rimm@channing.harvard.edu
10 Asia Pac J Clin Nutr. 2004;13(Suppl):S87
Folic acid deficiency is genotoxic and increases sensitivity to chromosome damage by gamma-radiation
Beetstra S, Fenech M
11 The Journal of Nutrition Vol. 127 No. 2 February 1997, pp. 199-201
E. L. Robert Stokstad (1913-1995)
Barry Shane and Kenneth J. Carpenter
12 Pharmacogenomics. 2005 Oct;6(7):673-689
Pharmacogenetics of folate-related drug targets in cancer treatment
Robien K, Boynton A, Ulrich CM.
13 http://www.chemheritage.org/EducationalServices/pharm/chemo/readings/ages.htm
Cancer Chemotherapy:A Chemical Needle in a Haystack
The Chemical Heritage Foundation, 2001
14 Cochrane Database Syst Rev. 2003;(4):CD004514. Review
Folic acid with or without vitamin B12 for cognition and dementia
Malouf M, Grimley EJ, Areosa SA.
Dept. of Clinical Geratology, Cochrane Dementia and Cognitive Improvement Group,
Radcliffe Infirmary, Woodstock Road, Oxford, UK, OX2 6HE
15 Trends Parasitol. 2005 Jun;21(6):292-8
Comparative folate metabolism in humans and malaria parasites (part I): pointers for malaria treatment from cancer
chemotherapy
Nzila A, Ward SA, Marsh K, Sims PF, Hyde JE.
Kenya Medical Research Institute and Wellcome Trust Collaborative Research Program, Wellcome Trust Research
Laboratories, PO Box 43640, Nairobi GPO 00100, Kenya
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Copyright 2008, William Bruneau
Folic acid folate homocysteine folinic acid NTD neural tube defects cancer heart disease